Esterification TMSCl

A variety of reagents have been reported for the transformation of amino acids into amino acid methyl esters. I used different ways for esterification of cystine which includes: 1) amino acid +.. communication we report that trimethylchlorosilane (TMSCl) with methanol at room temperature is an efficient reagent for esterification of amino acids of all classes. Compared to the methods mentioned above the use of TMSCl/MeOH was more advantageous due to the following features: easy operation According to a published report esterification of protected amino acids by TMSCl showed little racemization . It would of course be more interesting if free amino acids could be directly esterified with little racemization and work to determine if this is possible is currently under way in our lab and the results will be reported in due course Mechanism of Methyl Esterification of Carboxylic Acids by Trimethylsilyldiazomethane. †. Erik Kühnel, School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK, Fax: (+44) 117-929-8611. Search for more papers by this author Unfortunately, even in the simplest case (p-toluenesulfonic acid), esterification with methanol and TMSCl gave only unreacted starting material, as evidenced by 1 H-NMR and infrared spectroscopy

Minimal hazard: A deuterium-labeling study reveals that, contrary to prior assumption, the safe, reliable, and widely adopted method for methyl esterification of carboxylic acids using trimethylsilyldiazomethane (TMS CHN 2) proceeds through the concurrent acid-catalyzed methanolytic liberation of diazomethane (see scheme). Volume 46, Issue 37 A series of amino acid methyl ester hydrochlorides were prepared in good to excellent yields by the room temperature reaction of amino acids with methanol in the presence of trimethylchlorosilane... Trimethylsilyl chloride, also known as chlorotrimethylsilane is an organosilicon compound ( silyl halide ), with the formula (CH 3) 3 SiCl, often abbreviated Me3SiCl or TMSCl. It is a colourless volatile liquid that is stable in the absence of water. It is widely used in organic chemistry

How can esterification of serine hydroxide be achieved by

  1. A convenient and efficient sonochemical method for methyl esterification of carboxylic acids is catalyzed by polymer-supported triphenylphosphine in the presence of 2,4,6-trichloro-1,3,5-triazine and Na 2 CO 3. Methyl esters of various carboxylic acids bearing reactive hydroxyl groups as well as acid- or base-labile functionalities could be rapidly prepared within short times in good to excellent yields in high purities without column chromatography
  2. the presence of TMSCl (0.5 equiv) with out any solvent (Scheme-I). After 3 hours only 27% of octahydroquinazolinone product was isolated. Increasing the amount of TMSCl (1.5 equiv) did not improve the product yield to a considerable amount. Subsequently, we investigated the effec
  3. The acylium ion is the highly active intermediate shared by esterification and hydrolysis. ESI-MS data for several typical carboxylic acids confirmed that their acylium ions are easily generated. For 2,4,6-trialkylbenzoic acid and its ester, the two unsubstituted carbons in the benzene ring are very easily protonated, and we have thus revealed the root of the success of Newman's method. Based.
  4. ones and isatins in alcohols/water has been developed. The improved Pfitzinger reaction involves esterification and cyclization in one-step process, and in situ formed a carboxylic ester/acid group (CO 2 R or COOH) at the 4-position of quinoline ring
  5. o acids also proceeded smoothly in CH 2 Cl 2 at room temperature by using 2 equiv. of an alcohol and 5 equiv. of TMSCl against a carboxylic acid to give the desired ester quantitatively

Even taking into acct the lack of toxicity of our undesirable byproducts, the DMAP was an impressive catalyst for acylation and ESTERIFICATION that I still would have chosen to work with it out of the convenience of performing rapid room temp acylations with minimal pyridine and easy workup. DMAP is also highly effective in N-acylations with similar benefits in efficiency and yield. I've read. Ester Coupling Reactions- an Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products Journal: Natural Product Reports Manuscript ID: NP-REV-08-2014-000106.R A strong mineral acid catalyses the reaction by protonating the acid and promoting attack of the alcohol on the carbonyl. You can also use HCl, although obviously dry HCl is harder to handle (which is why we generate it in situ by adding TMSCl or a drop of SOCl2). Adding conc H2SO4 to an alcohol is extremely exothermic so dropwise addition with. Esterification. J. Cervera Villan... Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 35 Full PDFs related to this paper. Read Paper. Esterification. Download.

A Convenient Synthesis of Amino Acid Methyl Ester

  1. 8 TMSCl (2.0) MeCN, rt, 65 h 33 (59) 9 TMSOTf (2.0) MeCN, Et3Nb, rt, 65 h 80 (10) aYields of recovered starting material (s. m.) given in parentheses. bEt 3N (1 equiv) was added. Scheme 5: Plausible mechanism of the Lewis acid-promoted Pinner reaction. the Brønsted acid trifluoromethanesulfonic acid is to b
  2. + TMSCl R OTMS O + HCl R'OH/H+ R OR' O + TMSOH TMSCl TMS2O + HCl Scheme 1.9 A similar protocol is available with TMSCl (trimethylsilyl chloride) (Scheme 1.8 ) [9] . In this case, TMSCl is added to a mixture of alcohol and carboxylic acid. It has been suggested that the reactant alcohol works as a proton donor as well. On th
  3. When azobenzene was treated with two equivalents of the system composed of Ni(glyme)Cl 2, 1,10-phenanthroline, and Zn (activated with 1 mol% of TMSCl) at 90 °C, a reaction seemed to occur but it.

Conventional esterification catalyzed by toluene-4-sulfonic acid failed due to low solubility of initial acids. Furthermore, earlier work provided dimethyl ester 6 in lower yields of 68% and 59%, 10respectively. Therefore, we carried out the reaction in the presence of trimethylsilyl chloride (TMSCl, 2 eq.) in neat methanol under reflux (Scheme 2). This method was already applied in the. acyloin-condensation. RSC ontology ID. RXNO:0000085. Acyloin condensation is a reductive coupling of two carboxylic esters using metallic sodium to yield an α-hydroxyketone, also known as an acyloin. The reaction is most successful when R is aliphatic and saturated. The reaction is performed in aprotic solvents with a high boiling point, such. TMSCl, THF 2) 1N HCl 83 % 1 1) TMSCl, THF 2) L-Selectride 3) aq. HF, CH 3CN 58 % 2 Scheme 1 There are three main classes of organozinc compounds:5 organozinc halides (RZnX), diorganozincs (R 2Zn) and lithium or magnesium zincates. Organozinc halides are readily available by the direct insertion of zinc dust into organic halides6 (Scheme 2) Indeed, highly reactive Rieke zinc can be formed by.

The esterification was performed as described in (methanol, 2,2-dimethoxypropane, TMSCl, 3 days at ambient temperature). However, since both trimethyl esters of ICIT and CIT ( 3 and 4 , resp.) have a high solubility in water (see below), the necessary washing steps during work-up should be performed with minimum volumes of aqueous solutions and water when bromotrimethylsilane (TMSBr) or TMSCl/NaBr was used in place of TMSCI. However, when NaI was used along with TMSCI in the reaction, iodides were formed as has been observed earlier by Olah et all7. Under present reaction conditions, when aromatic acids 6' were subjected to esterification with methanol . NOTES 681 or ethanol, no reaction took place and the starting ma­ terials were.

MeOH, TMSCl 0 °C to r.t., 5 h TMSO O N N H O Ot-Bu MeO O N N H O Ot-Bu O N NH2 †2HCl 99% yield †HCl †HCl Synthesis of (R)-3-(3-pyridyl)alanine methyl ester dihydrochloride Substrate scope SYNFACTS Contributors: Hisashi Yamamoto, Isai Ramakrishna Synfacts 0172021, 17(07), 0833 Published online: 17.06.2021 1861-19581861-194X DOI: 10.1055/s-0040-1706223; Reg-No.:H04821SF Georg Thieme. Readily formed by trapping a lithium enolate with TMSCl. d is responsible for O-alkylation being the major product. • Enolates are ambident nucleophiles and can re • SOFT electrophiles (e.g. mo • HARD electrophiles tend to react at Oxygen (hard centre). 4.1. Silyl Enol • The strong Si-O bon ci) esterification of: i) carboxylic acids with alcohols in the presence of an acid catalyst (e.g. concentrated H₂SO₄) Scotland. Higher. SQA Chemistry. 2. Nature's chemistry (d) Esters, fats and oils. Esters are formed by a condensation reaction between an alcohol and a carboxylic acid. Wales. A/AS level. WJEC Chemistr Conversion of tert-butyl esters to other functional groups. The reaction of tert-butyl esters with SOCl 2 at room temperature provides acid chlorides in very good yields, whereas benzyl, methyl, ethyl, and isopropyl esters are essentially unreactive. J. A. Greenberg, T. Sammakia, J. Org. Chem., 2017, 82, 3245-3251

Synthesis of Citreofuran by Alois Fürstner (2003)

Molecules Free Full-Text A Convenient Synthesis of

INFORME DE LABORATORIO DE QUIMICA ORGANICA 2 universidad nacional de ingeniería facultad de ingeniería química textil departamento académico de ingenierí The transformation of secondary amides has been a long-time challenging topic and only the O-esterification or O-etherification strategy using Tf 2 O or TMSCl has been succeeded the activation of.

Synthesis of Cyclic Aminoacid Derivatives via Ring Closing

Mechanism of Methyl Esterification of Carboxylic Acids by

CuBr•DMS, TMSCl HMPA/THF, -78 °C 64% yield 9:1 dr O OTBS H3C LiTMP, TESCl THF, —78 °C 66% yield TESO OTBS H3C 8 9 10 DDQ, HMDS 84% yield PhMe, 23 °C O OTBS H3C 11 1. NaBH4, CeCl3•7H2O MeOH, -78 °C 2. TBAF, THF, 60 °C 78% yield over 2 steps, >20:1 dr HO OH H3C 6 10 2 steps from (R)-linalool (ref 11) 5 steps from (R)-carvone (ref 13) A. B. Page 2 of 7 ACS Paragon Plus Environment. オルトエステルは酸触媒下加水分解されて対応するアルコールを放出してギ酸エステルになります。したがって、脱水作用とアルコール放出作用を持ちます。 この性質を利用して酸触媒下、あるいは加熱のみでオルトエステル単独あるいはアル.

Esterification of Sulfonic Acids (Methyl Tosylate, Ethyl

TMSCl, Mn, 3 Å MS THF, then aq. HCl Ar OH >92% yield 69-97% ee M=Cu, R 1=t-Bu R 2=t-Bu, R 3=H O alkyl/aryl H CH 3NO 2 cat. 10 mol% 4 Å MS, MeOH, 40 oC 81-99% yield >91% ee + + + alkyl/aryl NO 2 OH Org. Lett. 2012, 14, 6270 Org. Lett. 2011, 13, 2488 alkyl/aryl alkyl/aryl O + R SH cat. 20 mol% DCE, -5 oC 89-98% yield >93% ee alkyl/aryl alkyl/aryl SR O [C/O] Ar N 2CHCO 2Et cat. 5 mol% KSAc 5. Fisher esterification (RCOOH + R'OH + H+) Acid chloride + ROH, pyridine t-Butyl esters: isobutylene, H+ Methyl esters: diazomethane Carboxylic Acid Protection Formation: Cleavage:t-Butyl: cleaved by moderately acidic hydrolysis Others: LiOH, THF, H 2O enzymatic hydrolysis t-Butyl: stable to mild base and ammonia Others: stable to acid 9-Fluorenylmethyl Esters (Fm) Stability: Cleavage: Fm is. RO Si i-Pr i-Pr i-Pr RO Si Et Et i-Pr RO Si CH3 CH3 CH3 ROH ROH O Si O O Si i-Pr-Pr i i-Pr R R RO Si CH3 CH3 t-Bu RO Si Et Et Et RO Si CH3 CH3 i-Pr RO Si Ph Ph t-Bu O R O R Si t-Bu t-Bu Myers Protective Groups - Silicon-Based Protection of the Hydroxyl Group Chem 115 General Reference: Greene, T. W.; Wuts, P. G. M. Protective Groups In Organic Synthesis, 3rd ed. John Wiley & Sons: New York. TMSCl FeCl3 MeMgBr Reaction with radical N N Ph Ph Δ or hυ PhPh HONO esterification Furoxans. Hai Dao Baran Group Meeting Nitroso and Nitro Compounds 11/22/2014 N-Nitrosoamine (secondary amine derivatives) HN CN NaNO2 CNHCl N ON Fischer-Hepp rearrangement NO D'Amico et al. J. Am. Chem. Soc. 1959, 81, 5957-5963. S-Nitrosothiols (thionitrites) HO N H OH O NH2 O O O S N O S. Etude de la protection des fonctions alcool, carbonyle et amine en chimie organique. Le but d'une protection est de préserver une fonction intacte. Ainsi, en protégeant une fonction on la préserve en l'empêchant de réagir. La fonction ainsi protégée n'est plus la fonction d'origine, elle ne réagit donc plus de la même façon.

(PDF) A Convenient Synthesis of Amino Acid Methyl Ester

- 4 - - 5 - Trimethylsilylation Trimethylsilylating Reagents (A5000 series) Gas Chromatography (GC) is widely used for analysis of various kinds of samples 椎名エステル化反応(しいなエステルかはんのう、英: Shiina esterification)とは有機化学における化学反応のひとつで、芳香族カルボン酸無水物を脱水縮合剤に用いたエステルの合成法である。 1994年にルイス酸触媒を用いる手法が 、2002年に求核性触媒を用いる手法が椎名勇によって報告され

esterification. The biodiesel obtained had good acidity characteristics and low sulfur content. Additionally the need for a pretreatment to Luna Azul ISSN 1909-2474 No. 40, enero - junio 2015 ©Universidad de Caldas 25. oils and biodiesel purification to achieve compliance of international standards was evidenced. KEY WORDS Waste oils, esterification, transesterification, biodiesel. Convenient one-step synthesis of pyrrolo[3,4-c]quinolin-1-ones via TMSCl-catalyzed cascade reactions of isatins and β-enamino ketones. RSC Adv., 2016, 6, 73760-73768. 16). Xu Hui, Zhou Bei, Zhou Pan, Zhou Jie, Shen Yuehai, Yu Fuchao*, Lu Lingling. Insights into the unexpected chemoselectivity in br?nsted acid catalyzed cyclization of isatins with enaminones: convenient synthesis of pyrrolo. The resulting crude diethyl malonate derivative was reacted with sulfuric acid in the presence of methanol at 200 °C which resulted in a hydrolysis, decarboxylation and esterification sequence to produce methyl ester 15. Treatment of 15 with LDA produced the enolate which was trapped with TMSCl to give silyl enol ether 16 Who We Are. Gaylord Chemical Company, LLC is the world's preeminent producer of Dimethyl Sulfide, Dimethyl sulfoxide, and Procipient. Gaylord's history dates back to 1962 when under the ownership of Crown Zellerbach, began an aggressive and comprehensive research program into the manufacture of Dimethyl Sulfide (DMS), Dimethyl Sulfoxide.

Symposium on the chemistry of natural products NII-Electronic Library Service Symposlum on naturalthe ohemlstry of produots 33 抗腫瘍活性マ クロライドPladienolide BおよびD の全合成 (エーザイ筑波研) 0伊藤大輔 、 Kanada Regina M. 、 永井光雄 、 新島 Dialkyl sulfoxide synthesis: TMSCl / H2O2 oxidation. Diarylalkynes by decarboxylative coupling in DMSO. Dichlorocyclopropene Activation of DMSO for Swern Type Oxidations; Dieckmann Cyclization Comparative Reaction; Direct C-H activation and C-S bond formation catalyzed by DMSO/I2; Direct Conversion of Haloarenes to Phenols with Acetohydroxamic. After 1.5 h, TMSCl (25 µL, 0.20 mmol) was added. The mixture was stirred at -78 ˚C for 20 min, then at 0 ˚C for 10 min. The reaction mixture was diluted with hexanes (20 mL). The organic layer was washed with 1 M HCl (2 × 2 mL), followed immediately by sat. aq NaHCO 3 (10 mL), dried with Na 2 SO 4, and concentrated. The residue was. Table 2: Esterification of alcohols 40, 41 and 42 and Ireland-Claisen rearrangement. Reagents and conditions: a) EDC·HCl, DMAP, carboxylic acid, CH 2 Cl 2, rt, 15-22 h; for 52: silylation of the free hydroxy group at C14: imidazole, TBSCl, DMAP, DMF, rt, 40 h; b) KHMDS, TMSCl, toluene, −78 °C to 85 °C, ca. 18 h — Readily available methoxy-, benzyloxy-, and allyloxyesters (I), (V), (IX), and (XIII) undergo rearrangement by treatment with LDA and TmsCl to give sensitive acids which afford after esterification purifiable esters in which the ketone moiety is unmasked. Benzyloxy and allyloxy products (XI) and (XV) are debenzylated and deallylated to give the title ketoesters (XII). — (BROADHURST.

Name matches: pyridine trimethylchlorosilane. Rapid qualitative analysis of 2 flavonoids, rutin and silybin, in medical pills by direct analysis in real-time mass spectrometry (DART-MS) combined with in situ derivatization. PMID 29285822; Journal of mass spectrometry : JMS 2018 Mar; 53 (3):240-246 Cerium(III)-Catalyzed Addition of Diethylzinc to Carbonyl Compounds1 . CeCl 3 catalyzes the addition of Et 2Zn to a variety of alipahtic and aromatic aldehydes and ketones in THF in the presence of TMSCl as a scavenger

Trimethylsilyl chloride - Wikipedi

We report herein an improved Pfitzinger reaction for the synthesis of highly functionalized quinaldines from 1,3-dicarbonyl compounds, isatins and alcohols mediated by TMSCl. This synthesis involves cyclization and esterification in one-step cascade process for the formation of a carboxylate (CO2R) at the 4-position of quinaldine ring. Moreover, this procedure shows highly efficient, good. ez0tmscl.543kk.ne

Ester synthesis by esterificatio

TMSCl mediated highly efficient one-pot synthesis of

(dichloromethyl)lithium and then esterification following work-up. A nucleophilic substitution of chlorine using an organometallic reagent led to the α-chloroalkyl boronate. Displacement of the remaining chlorine using an azide led to the α-azidoalkyl boronate, which was subsequently converted to the -azido-α-chloroalkyl boronate after homologation. Selective reduction of the chlorine. H N N H O F H3C CH3 O CO2CH3 OTBS O2N O O CH3 Br CO2H H H N N H O H3C CH3 O OTBS O2N OH F CO2H HN SO2 CH2OH HN SO2 O O CH3 Br CH2OTHP H Mark G. Charest, Fan Liu Lithium Borohydride: LiBH4 • Lithium borohydride is commonly used for the selective reduction of esters and lactones to th

Acid-catalyzed carboxylic acid esterification and ester

NPC Natural Product Communications Vol

Esterification Fragmentation Kende et. al. N H H O O Me N H HMe MeO2C O N O H HMeH Kende Intermediate H3CO O O H3CHN H C H3 H H3CO O O CH3 H OH O HO Reduction Es terifcaon Ep imerzaton Vinyl Addition Oxidatve Cleavg R eductiv Closure Hydrolysis Reduction Oxidative Cleavage Aldol Amination DA Oxidation. Group Meeting O'Malley 2/25/2004 Dendrobine Retrosynthesis N H H O O Me Martin and LI N H. All products of the esterification of Fmoc-glycine (entry 7-13) with different alcohols and donor or acceptor substituted phenols were essentially 100% pure, except for tert-butyl alcohol, which reacted only after the addition of 0.25 equivalents of DMAP. The conversion was slow, but the resulting ester was of good purity. Scheme 1: The example described in the experiment illustrates the. ºC, 52%; (c) TMSCl / MeOH, 91% 4 :4 1:2; (d) NaOMe / MeOH, 82%; (e) H 2O 2 / H 2O, 92%. The L-isomer was synthesised from the known benzylidene acetal-protected methyl glycoside 7 (Scheme S2).2 Oxidative ring opening of the benzylidene acetal provided the 5-bromo derivative 8 which was treated with sodium thiomethoxide. In this case a longer.

An improved Pfitzinger reaction for the direct synthesis

O NaH, TMSCl Hexanes, 0ºC 92% OTMS 'hyperstable olefin' Sodium Bis(dimethylglyoximato)-(pyridine)cobaltate supernucleophilic cobalt complex;reagent for preparation of alkyl(dmg)2(pyridine)cobalt(III) complexes- (alkylcobaloximes) and for formation of metal-cobalt bonds; reducing agent; reagent for reductive formation of carbon-carbon bonds, initializing ring expansions from cyclic. Shiina esterification Migita-Kosugi-Stille coupling acid-mediated spiroketalization epoxide rearrangement ascospiroketal B O O O O O OH O H H H OH Letter 1730 Synlett 2020, 31, 1735-1739 DOI: 10.1055/s-0040-1706415 N. Ogawa* S. Sone S. Hong Y. Lu Y. Kobayashi Meiji University, Japan Synthesis of Two Stereoisomers of Potentially Bioactive 13,19,20-Tri-hydroxy Derivative of Docosahexaenoic. Our synthetic path started with the one-pot esterification and intramolecular cyclization of commercially available D-glutamic acid to render (R)-Pyroglutamic ethyl ester in quantitative yields. Amide bond alkylation proceeded smoothly under standard conditions to give the functionalized lactam 23. As expected, a chemoselective doubl The Reaction between Sodium Metal and Ethanol. If a small piece of sodium is dropped into ethanol, it reacts steadily to give off bubbles of hydrogen gas and leaves a colorless solution of sodium ethoxide: C H 3 C H 2 O N a. The anion component is an alkoxide. If the solution is evaporated carefully to dryness, then sodium ethoxide ( C H 3 C H.

TMSCl as a Mild and Effective Source of Acidic Catalysis

Since treatment of 5 with trimethylsilyl chloride (TMSCl) in methanol, a -lactam 6 rather than the expected diester was obtained. To avoid the cyclization during the esterification, we switched the sequence and intended to hydrolyze the isocyano group to amino group first, followed by protection of amino group. The isocyano group in 5 can be easily hydrolyzed into free amino group in HCl/MeOH. General Characteristics-Serving as effective protective groups for alcohols, silyl ethers are used extensively in laboratory scale synthesis.-At least two of the three R' groups are the same group, because if all three were different the silicon atom would be stereogenic and could give rise to diastereomers, which would complicate handling of the compound The synthesis of 11-epi-lyngbouilloside 8 began by first converting 2,2,6-trimethyl-4H-1,3-dioxin-4-one 9 to the corresponding silyl dienol ether (LDA, TMSCl, THF, −78°C) and subjecting the latter to 4-pentenal under asymmetric vinylogous aldol conditions (Denmark et al., 2005a,b).Among the various enantioselective catalytic processes developed so far in the field of asymmetric Mukaiyama. Esterification of 14 with TEA resulted in the formation of cage-like structure 4 which on treatment with KHMDS and MeI followed by KHMDS and allyl iodide produced olefin 16. Vinyl pinacol boronate and 16 reacted in presence of the Grubbs second generation catalyst to produce vinyl boronate 19 which on reacting with trimethylamine N-oxide gave 20. Following Pinnick protocol 20 was converted to.

Organic Chemistry 1 and 2 Study Guides Include. 1. Lewis Structures, Resonance Structures, and Formal Charges. Following a few steps to draw Lewis structures, Formal Charges and a table to quickly identify them, Resonance Structures, Resonance hybrid, Curved Arrows and the rules for drawing resonance Structures, a Complete Guide for Assessing. In the Fischer esterification of carboxylic acids, an acid is used as a catalyst. Draw curved arrows to complete the mechanism for the Fischer esterification of acetic acid with ethanol. Is the protonated or nonprotonated carboxylic acid more electrophilic? Why is the acid necessary for the reaction to proceed? 66. In medicinal chemistry, chemists often perform structure-activity relationship. To Sum Up: SN1 vs SN2 Mechanisms According to Steric Effects. In short, substitution reactions are simple exchanges of functional groups, such as different halogens. If steric effects allow it, these reactions take place through SN2 bimolecular concerted mechanism, which gives inversion of configuration. If steric hindrance is too high for this. TMSCl . J. Org. Chem. 2001, 66, 3747. アルコール溶媒中、TMSCl を2等量作用させ、エステルを合成する方法。 まず最初に、トリメチルシリルエステルが形成し、 続いてアルコールがシラノールを置換、エステルが生成する。 5. 活性エステル(縮合剤) ex. ChemBioChem 2012, 13, 2527. 活性エステルもエステル合成. TMSCl works as an acid catalyst precursor for selective esterification of L-aspartic and L-glutamic acids in the presence of primary, secondary and tertiary alcohols. Although excess TMSCl was required for the completion of esterification, the resulting alkyl TMS ether could be azeotropically removed by simple evaporation with alcohol. Web of Science. researchmap. Product Selectivity of.